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动物实验结果表明,丙型肝炎病毒(HCV)在黑猩猩慢性感染期间可发生核苷酸顺序变异,也能够发生基因型突变。为查明HCV在慢性感染的人体内是否也会象在灵长类体内那样发生基因型改变而进行了此项研究。 研究对象为日本Komagome医院肝病科使用第2代ELISA检测血清显示HCV抗体为阳性的265例慢性感染者,其中包括136例慢性肝炎患者,93例肝硬变患者和36例肝细胞癌患者。对受试者观察1～15年(平
Animal experiments show that the hepatitis C virus (HCV) in chimpanzees can occur during chronic infection nucleotide sequence variation, but also genotypic mutations can occur. The study was conducted to determine if HCV also changes genotypes in chronically infected humans as it does in primates. The study was conducted in 265 patients with chronic hepatitis C virus (HCV) positive by the second generation of ELISA in the Department of Hepatology, Komagome Hospital of Japan, including 136 patients with chronic hepatitis, 93 patients with cirrhosis and 36 patients with hepatocellular carcinoma. Subjects observed 1 to 15 years (flat