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胸腺素为胸腺分泌的一族多肽和蛋白质类激素,它与机体的免疫功能密切相关。随着免疫学的深入和发展,胸腺素也日益受到医药界的重视。1966年美国AL Goldstein等从小牛胸腺中提取了胸腺素,1974年开始将小牛胸腺素F_5用于临床试验。到目前为止,共试验了50多例原发性免疫缺陷病和150多例癌症,最近又试验了6例自身免疫性疾病。在原发性免疫缺陷病中,除重症联合免疫缺陷病外,大多有一定疗效,所治疗的肿瘤病人中,有部份病例表现临床症状及免疫指标的改善,可延长肺癌病人的生存期。现在,他们正在增加病例,进一步观察疗效,以正确评价胸腺素的治疗作用。
Thymosin is a family of peptides and protein hormones secreted by the thymus, which is closely related to the body’s immune function. With the deepening and development of immunology, thymosin is also increasingly valued by the pharmaceutical industry. In 1966, AL Goldstein from USA extracted thymosin from the calf thymus. In 1974, calf thymosin F_5 was used in clinical trials. So far, a total of 50 cases of primary immunodeficiency disease and more than 150 cases of cancer have been tested, and recently 6 cases of autoimmune diseases have been tested. In the primary immunodeficiency disease, in addition to severe combined immunodeficiency disease, most have a certain effect, the treatment of cancer patients, some cases of clinical symptoms and immune indicators to improve and extend the survival of patients with lung cancer. Now, they are adding cases to further observe the effect, in order to correctly evaluate the therapeutic effect of thymosin.