妊娠期凝血功能的改变是子痫前期发病机制中重要环节,采用抗凝治疗可以有效预防妊娠期高血压疾病及其并发症的发生。低分子肝素和小剂量阿司匹林是目前应用较多的抗凝药物,作者从循证医学的角度评价这两种药物在子痫前期抗凝治疗中的安全性和有效性。 Changes in coagulation during pregnancy is an important part of the pathogenesis of preeclampsia, the use of anticoagulant therapy can effectively prevent pregnancy-induced hypertension and its complications. Low-molecular-weight heparin and low-dose aspirin are more commonly used anticoagulants. The authors evaluated the safety and efficacy of these two drugs in anticoagulant therapy of eclampsism from the perspective of evidence-based medicine.