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目的:探讨上皮性卵巢癌组织中VEGF-C和p53蛋白表达及与临床病理因素、预后的相关性。方法:应用S-P免疫组织化学染色法检测上皮性卵巢癌32例、交界上皮性卵巢瘤10例、良性上皮性卵巢瘤14例及正常卵巢上皮组织10例VEGF-C和p53蛋白的表达。结果:恶性及交界性卵巢组织中VEGF-C和p53中-高度阳性表达率分别为71.86%(23/32)和59.38%(19/32)、20.00%(2/10)和60.00%(6/10),而良性上皮性卵巢肿瘤和正常卵巢上皮组织中均无VEGF-C和p53中-高度阳性表达。VEGF-C与p53蛋白表达呈正相关。结论:VEGF-C和p53中-高度阳性表达与卵巢癌患者腹水量、盆腹腔种植、淋巴结与远处转移相关。VEGF-C和p53蛋白中-高度表达可作为判断卵巢上皮癌预后的有价值指标。
Objective: To investigate the expression of VEGF-C and p53 in epithelial ovarian cancer and its correlation with clinicopathological factors and prognosis. Methods: The expressions of VEGF-C and p53 protein in 32 cases of epithelial ovarian cancer, 10 cases of borderline epithelial ovarian tumor, 14 cases of benign epithelial ovarian tumor and 10 cases of normal ovarian epithelial tissue were detected by S-P immunohistochemical staining. Results: The positive rates of VEGF-C and p53 in malignant and borderline ovarian tissues were 71.86% (23/32) and 59.38% (19/32), respectively. The positive rates of VEGF-C and p53 were 20.00% (2/10) and 60.00% / 10), but no positive expression of VEGF-C and p53 in benign epithelial ovarian tumors and normal ovarian epithelial tissues. VEGF-C and p53 protein expression was positively correlated. CONCLUSIONS: The high-positive expression of VEGF-C and p53 is associated with ascites, pelvic implantation, lymph node metastasis and distant metastasis in patients with ovarian cancer. VEGF-C and p53 protein - high expression can be used as a prognostic value of ovarian epithelial cancer a valuable indicator.