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目的明确艾滋病(AIDS)儿童抗病毒药物的治疗效果,了解抗病毒治疗对AIDS儿童的生长发育情况的影响。方法符合治疗标准的AIDS儿童给予抗病毒治疗并随访2年,每半年对AIDS儿童的身高、体重及外周血CD4+T淋巴细胞、病毒载量等进行检测并分析,评估AIDS儿童抗病毒治疗效果及生长发育状况。结果AIDS儿童经一线方案抗病毒治疗后CD4+T淋巴细胞计数升高,较基线水平差异具有统计学意义(P<0.05),二线方案抗病毒治疗后CD4+T淋巴细胞较基线水平差异无统计学意义(P>0.05)。AIDS儿童基线身高、体重均低于同龄正常儿童,差异具有统计学意义(P<0.05),经抗病毒治疗后身高、体重与同龄正常儿童差距减小,差异具有统计学意义(P<0.05)。结论抗病毒治疗能够有效提高AIDS儿童机体免疫力,提升儿童的生长发育水平;更早期、更长期的抗病毒治疗能否使AIDS儿童的生长发育水平达到正常,仍需开展进一步的研究。
Objective To clarify the therapeutic effect of antiviral drugs for children with AIDS and to understand the effect of antiviral therapy on the growth and development of AIDS children. Methods AIDS children who met the criteria of treatment were given antiviral therapy and were followed up for 2 years. The AIDS children’s height and weight, peripheral blood CD4 + T lymphocytes and viral load were detected and analyzed every six months to evaluate the effect of antiviral therapy on AIDS children And growth and development status. Results The number of CD4 + T lymphocytes in AIDS children after anti-virus treatment of first-line regimen was significantly higher than that of baseline (P <0.05). There was no significant difference in baseline level of CD4 + T lymphocytes after second-line regimen antiviral therapy Significance (P> 0.05). The baseline height and weight of AIDS children were lower than those of their normal children at the same age (P <0.05). The differences of height, weight and normal children after antiviral treatment decreased with statistical significance (P <0.05) . Conclusion Antiviral therapy can effectively improve the immune system of children with AIDS and enhance the growth and development of children. Whether the earlier and longer-term antiviral therapy can make the growth and development of AIDS children reach the normal level still needs further study.