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目的探讨鼻腔恶性黑色素瘤的临床病理特征,对其诊断和鉴别诊断进行讨论,以提高对该病的认识。方法收集我院1995年至2007年4例鼻腔恶性黑色素瘤病例,观察其临床病理特点并进行免疫组化分析。结果4例鼻腔恶性黑色素瘤中男性2例,女性2例,年龄37~77岁,70岁以上3例,37岁1例,病变主要发生于鼻腔,其中左鼻腔1例,右鼻腔3例,肿瘤由上皮样、梭形及未分化小细胞等多种类型的细胞构成,通常血管周围细胞呈瘤样结构。免疫组化标记瘤组织HMB45、S-100和V im均(+)。结论鼻腔恶性黑色素瘤是鼻腔的罕见疾病,通常诊断较困难,根据其组织学改变和免疫组织化学染色可有助于与鼻腔其他原发肿瘤相鉴别。
Objective To investigate the clinicopathological features of nasal malignant melanoma and to discuss its diagnosis and differential diagnosis in order to improve its understanding of the disease. Methods Four cases of nasal malignant melanoma from 1995 to 2007 in our hospital were collected. The clinical and pathological features were observed and analyzed by immunohistochemistry. Results In 4 cases of nasal malignant melanoma, there were 2 males and 2 females, ranging in age from 37 to 77 years. More than 70 years of age were in 3 cases and 37 years old in 1 case. The lesions mainly occurred in nasal cavity, including 1 case of left nasal cavity and 3 cases of right nasal cavity. Tumor from the epithelial like, spindle and undifferentiated small cells and other types of cells, usually perivascular cells were tumor-like structure. Immunohistochemistry labeled tumor tissue HMB45, S-100 and V im were (+). Conclusions Nasal malignant melanoma is a rare disease in nasal cavity. It is usually difficult to diagnose it. According to its histological changes and immunohistochemical staining, it can be helpful to differentiate it from other primary nasal tumors.