To evaluate the importance of the canyon topography effects on large structures, based on a rigid frame bridge across a 137-m-deep and 600-m-wide canyon, the seismic response of the canyon site is analyzed using a two-dimensional finite element model under different seismic SV waves with the assumptions of vertical incidence and oblique incidence to obtain the ground motions, which are used as the excitation input on the pier foundations of the bridge with improved large mass method. The results indicate that canyon topography has significant influences on the ground motions in terms of incident angle. The peak ground acceleration values vary greatly from the bottom of the canyon to the upper corners. Under vertical incident SV waves, at the upper corners of canyon the peak ground accelerations greatly increase; whereas the peak ground accelerations diminish at the bottom corners of canyon. Under oblique incident SV waves, the shaking of the canyon slope perpendicular to the incidence direction is much more severe than that of the opposite side of canyon. And the ground surface has been characterized by larger deformations in the case of oblique incident waves. It is also concluded that the low piers and frame of the continuous rigid frame bridge are more sensitive to the multi-support seismic excitations than the flexible high piers. The canyon topography as well as the oblique incidence of the waves brings the continuous rigid frame bridge severe responses, which should be taken into account in bridge design. To evaluate the importance of the canyon topography effects on large structures, based on a rigid frame bridge across a 137-m-deep and 600-m-wide canyon, the seismic response of the canyon site is analyzed using a two-dimensional finite element model under different seismic SV waves with the assumptions of vertical incidence and oblique incidence to obtain the ground motions, which are used as the excitation input on the pier foundations of the bridge with improved large mass method. The results indicate that canyon topography has significant influences on the ground motions in terms of incident angle. The peak ground acceleration values ​​vary greatly from the bottom of the canyon to the upper corners. The vertical ground acceleration values ​​vary greatly from the bottom of the canyon to the upper corners. Ground obliquity diminish at the bottom corners of canyon. Under oblique incident SV waves, the shaking of the canyon slope perpendicular to the incidence And the ground surface has been characterized by larger deformations in the case of oblique incident waves. It is also said that the low piers and frame of the continuous rigid frame bridge are more sensitive to the multi-support seismic excitations than the flexible high piers. The canyon topography as well as the oblique incidence of the waves brings the continuous rigid frame bridge severe responses, which should be taken into account in bridge design.