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目的:选择黏度适宜的高分子溶液,制备相转化水凝胶微针。方法:通过考察两种型号的聚乙烯醇本身的黏度性质、溶液温度、几种不同性质的高分子材料,包括透明质酸、预胶化淀粉等可能影响聚乙烯醇溶液黏度的因素,使用粘度计测定其黏度值并作图比较,观察溶液黏度变化的规律。将所制溶液分别制备微针以观察针形的好坏,选择合适制备相转化水凝胶微针的溶液黏度范围。结果:实验表明黏度范围在2.5万至13万m Pa·s之间的聚合物溶液较为粘稠且流动性适宜。结论:在该黏度范围内的聚合物溶液可用以制备相转化水凝胶微针,适用于工业化生产。
Objective: To select the appropriate viscosity of the polymer solution, prepare phase conversion hydrogel microneedles. Methods: By examining the viscosity properties of the two types of polyvinyl alcohol, temperature of the solution, several different types of polymer materials, including hyaluronic acid, pregelatinized starch and other factors that may affect the viscosity of polyvinyl alcohol solution, the viscosity The determination of the viscosity value and comparison chart, observe the change of the viscosity of the solution. The prepared solutions were prepared microneedle needle to observe the quality of the needle, select the appropriate phase transition hydrogel microneedle solution viscosity range. Results: Experiments have shown that the polymer solutions with viscosities ranging from 25,000 to 130,000 mPa · s are viscous and fluid. Conclusion: Polymer solutions in this range of viscosity can be used to prepare phase-transfer hydrogel microneedles for commercial production.