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5-(5′′-Substituted phenyl-[1′′,3′′,4′′]oxadiazol-2′′-yl methylsulfanyl)-3-pyridin-3′-yl- [1,2,4] triazol-4-yl amines 1a-j were quaternarized with methyl iodide to afford the corresponding methyl pyridinium salts 2a-j. The reduction of compounds 2 with NaBH4 in methanol gave the target compounds 5-(5′′-substituted phenyl-[1′′,3′′,4′′]oxadiazol-2′′-yl methylsulfanyl)-3-(1′-meth- yl-1′,2′,5′,6′-tetrahydropyridin-3′-yl)-[1,2,4]triazol-4-ylamines 3a-j. The endothelium vascular relaxing activity of the target compounds were screened.
5- (5 ’’ - Substituted phenyl- [1 “’3’ ’, 4’ ’oxadiazol-2’ ’- ylmethylsulfanyl) -3 -pyridin-3’-yl- [1,2,4] triazol -4-yl amines 1a-j were quaternarized with methyl iodide to afford the corresponding methyl pyridinium salts 2a-j. The reduction of compounds 2 with NaBH 4 in methanol gave the target compounds 5- (5 ’’ - substituted phenyl- [1 ’ Tetrahydropyridin-3’-yl) -, 3 ’’, 4 ”oxadiazol-2" -ylmethylsulfanyl) -3- (1’-meth- [1,2,4] triazol-4-ylamines 3a-j. The endothelium vascular relaxing activity of the target compounds were screened.