自从1980年诺氟沙星被发展成为抗菌剂以来,人们成功地合成了许多氟取代吡啶羧酸类化合物。其中9个已成为药物上市,还有5个处于开发阶段。日本大阪制药公司已合成了一系列新的5—甲基喹诺酮类化合物,OPC—17116是其中之一。抗菌活性 OPC—17116是一新型、具有广谱抗菌活性的5—甲基喹诺酮衍生物。它对革兰氏阴性、阳性菌及厌氧菌均显示强抑制作用。OPC—17116抗革兰氏阳性菌的活性强于环 Since 1980, norfloxacin has been developed into an antibacterial agent, many people have successfully synthesized a variety of fluorinated pyridine carboxylic acid compounds. Nine of them have become drug-listed and five are still in development. Osaka Pharmaceuticals Japan has synthesized a series of new 5-methyl quinolone compounds, OPC-17116 is one of them. Antibacterial activity OPC-17116 is a novel 5-methyl quinolone derivative with broad spectrum antibacterial activity. It is Gram-negative, positive bacteria and anaerobic bacteria showed strong inhibitory effect. The activity of OPC-17116 against Gram-positive bacteria is stronger than that of the loop