1例92岁男性患者因上消化道出血给予泮托拉唑、复方氯化钠注射液、维生素K_1、水溶性维生素、脂溶性维生素(Ⅱ)静脉滴注,5 d后停用泮托拉唑,改用埃索美拉唑40 mg+0.9%氯化钠注射液100 ml,1次/12 h静脉滴注。2 d后患者出现胡言乱语、幻觉和失眠。给予地西泮10 mg肌内注射,约1 h后上述症状有所好转。停用埃索美拉唑,其他药物继续应用,患者未再出现精神异常症状。 A 92-year-old male patient was given intravenous infusion of pantoprazole, compound sodium chloride injection, vitamin K 1, water-soluble vitamins, and fat-soluble vitamins (Ⅱ) due to upper gastrointestinal bleeding. , Switch to esomeprazole 40 mg + 0.9% sodium chloride injection 100 ml, 1/12 h intravenous infusion. Two days later, patients appeared nonsense, hallucinations and insomnia. Give diazepam 10 mg intramuscularly, about 1 h after the above symptoms have improved. Stop using esomeprazole, other drugs continue to apply, the patient no recurrence of mental symptoms.