类风湿性关节炎 (RheumatoidArthritis,RA)是以累及周围关节为主、多系统损伤的常见致残性自身免疫系统疾病。RA的基本病变是滑膜的慢性炎症及以破坏软骨、骨与周围组织的侵袭性血管翳的形成。RA中滑膜炎症的持续与加剧及单核细胞、淋巴细胞等炎细胞的浸润都依赖于血管床的存在 Rheumatoid arthritis (RA) is a common disabling autoimmune system disease involving mainly peripheral joints and multiple system injuries. The basic pathology of RA is the chronic inflammation of the synovium and the formation of aggressive blood vessels that destroy the cartilage, bone, and surrounding tissues. The persistence and aggravation of synovial inflammation in RA and the infiltration of inflammatory cells such as monocytes, lymphocytes and the like depend on the presence of the vascular bed