消炎痛抑制前列腺素合成,属非甾体抗炎药类宫缩抑制剂,许多安慰剂对照试验认为其有效并延迟分娩>48h,近期一些观察性研究揭示,其增加新生儿脑室内出血和坏死性小肠结肠炎发生率。由于方法学上的错误这些观察研究的结论应谨慎对待,最近的一项决策性分析支持其危险性及益处并存,消炎痛在早产的应用研究应进行精心设计的前瞻性临床试验。 Indomethacin inhibits prostaglandin synthesis, a non-steroidal anti-inflammatory drugs tocolytic, many placebo-controlled trials that its effective and delayed delivery> 48h, some recent observational studies have shown that it increases neonatal intraventricular hemorrhage and necrosis Intestinal colitis incidence. The conclusions of these observational studies should be treated with caution due to methodological errors. A recent decision-making analysis supports both the risks and benefits. Indomethacin in preterm labor should be carefully designed prospective clinical trials.