糖尿病的发病率逐年递增，其基本病理是胰岛素（Ins）分泌绝对或相对不足而导致糖代谢紊乱。胰岛素抵抗是正型糖尿病（NIDDM）发病的机理之一，受体和受体后缺陷是其重要病理生理特征[1]。本工作对NIDDM患者进行了葡萄糖耐量试验（OGTT），观察血浆血糖（BG）、Ins及靶细胞胰岛 The incidence of diabetes increased year by year, the basic pathology is insulin secretion (Ins) absolute or relative lack of glucose metabolism caused by disorders. Insulin resistance is one of the mechanisms of the pathogenesis of positive diabetes mellitus (NIDDM). Receptor and post-receptor defects are its important pathophysiological characteristics [1]. This work carried out in patients with NIDDM glucose tolerance test (OGTT), observed plasma glucose (BG), Ins and target cells islet