论文部分内容阅读
目的探讨老年慢性阻塞性肺疾病(COPD)急性加重期血清超敏C-反应蛋白(hs-CRP)水平的变化及其与肺功能变化的相关性。方法检测40例老年COPD急性加重期(AECOPD)患者、治疗后及40名健康体检者的血清hs-CRP含量、第1秒用力呼气容积(FEV_1)占用力肺活量(FVC)百分比(FEV_1/FVC)、白细胞计数(WBC)、红细胞沉降率(ESR)、动脉血气分析,并进行比较。结果CCPD急性加重期患者血清hs-CRP水平明显高于治疗后及健康体检者(P<0.05),治疗后FEV_1/FVC明显改善,血清hs-CRP变化与FEV_1/FVC成负相关(r=-0.710,P<0.05)。结论血清hs-CRP可作为COPD急性加重期诊断及疗效判断的指标。
Objective To investigate the changes of serum hs-CRP level and its relationship with the changes of lung function in the elderly with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods The serum levels of hs-CRP, FEV 1, FVC (FEV 1 / FVC) in 40 elderly patients with acute exacerbation of COPD (AECOPD) ), White blood cell count (WBC), erythrocyte sedimentation rate (ESR), arterial blood gas analysis, and compared. Results The level of serum hs-CRP in patients with acute exacerbation of CCPD was significantly higher than that of healthy controls (P <0.05). After treatment, FEV_1 / FVC was significantly improved. The change of serum hs-CRP was negatively correlated with FEV_1 / FVC (r = 0.710, P <0.05). Conclusion Serum hs-CRP can be used as an indicator of diagnosis and therapeutic efficacy in acute exacerbation of COPD.