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山莨菪碱(654-2)对二氧化硫吸入所致大鼠急性气管炎,角叉菜胶所致大鼠脚爪水肿,油酸所致大鼠急性肺损伤及博莱霉素A5所致肺纤维化均有保护作用。阻断组胺作用及抑制溶酶体酶的释放,可能是654-2抗炎症作用的部分环节。
Anisodamine (654-2) induced acute bronchitis, carrageenan-induced paw edema in rats induced by sulfur dioxide inhalation, acute lung injury induced by oleic acid and bleomycin A5-induced pulmonary fibrosis All have a protective effect. Blocking the action of histamine and inhibiting the release of lysosomal enzymes may be part of the anti-inflammatory effect of 654-2.