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目的:从病理形态学的变化研究补肾化痰中药对香烟烟雾吸入小鼠慢支模型的预防保护作用。方法:健康雄性小鼠60只,随机均分为正常对照组、慢支模型组、桂龙咳喘宁组、补肾化痰中药大剂量组和补肾化痰中药小剂量组,每组12只,采用香烟烟雾吸入法建立小鼠慢支模型,补肾化痰中药和桂龙咳喘宁均采用预防给药,光镜下观察各组小鼠气管和肺组织病理形态学的变化。结果:补肾化痰中药大、小剂量组和桂龙咳喘宁组小鼠气管和肺组织的病变程度均显著减轻(P<0.01或P<0.001),尤以补肾化痰中药大剂量组小鼠的效果最显著。结论:补肾化痰中药对烟熏慢支模型小鼠有显著的预防保护作用。
OBJECTIVE: To study the preventive and protective effects of traditional Chinese medicine for tonifying the kidney and resolving phlegm on cigarette smoke inhalation model in mice by pathological changes. METHODS: A total of 60 healthy male mice were randomly divided into normal control group, chronic bronchitis model group, Guilongkechuanning group, Bushenhuayu high-dose group, and Bushen Huayu traditional Chinese medicine low-dose group, 12 in each group. Cigarette smoke inhalation method was used to establish a chronic bronchitis model in mice. Bushen Huayu traditional Chinese medicine and Guilong Kechuanning were all administered prophylactically. Pathological changes of the trachea and lung tissues were observed under light microscope. RESULTS: The lesions of trachea and lung tissue in the mice of the Bushen Huayu Traditional Chinese Medicine Large and Small Dose group and Guilong Kechuanning group were significantly reduced (P<0.01 or P<0.001), especially in the large dose group of Bushenhuayu traditional Chinese medicine group. The effect of rats is most pronounced. Conclusion: Bushenhuayu has significant preventive and protective effects on smoked chronic bronchitis model mice.