论文部分内容阅读
目的:分析上海地区部分中老年糖尿病患者血矿物质水平变化。方法 :收集2016年1月1日至2016年11月30日至上海交通大学医学院附属瑞金医院中老年门诊体检的1 100名体检者,将其中2型糖尿病患者264例纳入糖尿病组,另836名非糖尿病体检对象作为非糖尿病对照组。所有观察对象均检测了血矿物质含量(钙、镁)及糖化血红蛋白(hemoglobin A1c,HbA1c),分析糖尿病组与非糖尿病组间的矿物质水平变化情况;糖尿病患者进一步以HbA1c≥7.0%为切点,分为血糖控制达标组(HbA1c<7.0%,192例)与未达标组(HbA1c≥7.0%,72例),进行亚组分析,并观察HbA1c与体内矿物质间的相关性。结果:与非糖尿病组相比,糖尿病组血钙水平较高[(2.36±0.14)mmol/L比(2.35±0.10)mmol/L],血镁水平较低[(0.85±0.07)mmol/L比(0.89±0.06)mmol/L],差异均有统计学意义(P<0.05,P<0.01)。以HbA1c≥7.0%为切点,糖尿病患者中,血糖控制达标组及未达标组之间的血钙、血镁水平差异均有统计学意义[分别为(2.35±0.14)mmol/L比(2.40±0.11)mmol/L、(0.87±0.07)mmol/L比(0.83±0.07)mmol/L;P均<0.01]。线性相关分析显示,所有研究对象的HbA1c与血钙水平呈正相关,与血镁水平呈负相关(r=0.074,P<0.05;r=-0.120,P<0.01)。结论 :与非糖尿病者相比,糖尿病患者体内的血镁水平偏低,血钙水平偏高;与血糖控制达标的糖尿病患者相比,血糖控制未达标的糖尿病患者体内血镁水平偏低,血钙水平偏高。上海部分中老年居民血HbA1c水平与血钙正相关,与血镁水平呈负相关。
Objective: To analyze the changes of blood mineral levels in some middle-aged and elderly diabetic patients in Shanghai. Methods: A total of 1,100 medical examinations from January 1, 2016 to November 30, 2016 at the outpatient clinics at the Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine were collected. Two hundred and sixty-two type 2 diabetic patients were included in the diabetic group and another 836 Non-diabetic physical examination as a non-diabetic control group. All subjects were examined for blood levels of minerals (calcium and magnesium) and hemoglobin A1c (HbA1c), and to analyze changes in mineral levels between diabetic and nondiabetic patients. Patients with diabetes were further treated with HbA1c ≥7.0% The subjects were divided into blood glucose control group (HbA1c <7.0%, 192 cases) and non-compliance group (HbA1c≥7.0%, 72 cases). The subgroups were analyzed. The correlation between HbA1c and minerals in the body was also observed. Results: Compared with non-diabetic group, the level of serum calcium was higher in diabetic group [(2.36 ± 0.14) mmol / L vs (2.35 ± 0.10) mmol / L) and lower level of serum magnesium (0.85 ± 0.07 mmol / L (0.89 ± 0.06) mmol / L], the difference was statistically significant (P <0.05, P <0.01). With HbA1c≥7.0% as the cut-off point, there were significant differences in blood calcium and serum magnesium levels between diabetic patients and non-compliance patients (2.35 ± 0.14 mmol / L vs 2.40 ± 0.11) mmol / L, (0.87 ± 0.07) mmol / L (0.83 ± 0.07) mmol / L, P <0.01]. Linear correlation analysis showed that there was a positive correlation between HbA1c and serum calcium level in all the subjects and a negative correlation with serum magnesium level (r = 0.074, P <0.05; r = -0.120, P <0.01). CONCLUSIONS: Compared with non-diabetic patients, the level of serum magnesium in diabetic patients is low and the level of serum calcium is high. Compared with diabetic patients with glycemic control, blood magnesium levels in patients with uncontrolled glycemic control are low, High calcium levels. The blood levels of HbA1c in some middle-aged and elderly residents in Shanghai were positively correlated with serum calcium and negatively correlated with serum magnesium levels.