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目的初步探讨糖尿病下肢动脉病变与血瘀证的关系,为临床早期防治糖尿病下肢动脉病变提供依据。方法对纳入的459例糖尿病患者进行基本信息和中医临床信息的采集及下肢动脉病变临床诊查。辨证分型为兼血瘀证组和无血瘀证组。对其中147例患者进行下肢动脉病变相关指标检测。观察糖尿病下肢动脉病变与血瘀证之间的关系。结果近75%的糖尿病患者合并有血瘀证。兼血瘀证组糖尿病下肢动脉病变(DLEAD)的患病率明显高于无血瘀证组(P<0.01)。血瘀对DLEAD危险度估计的OR值为4.737。兼血瘀证组外周动脉疾病的患病率明显高于无血瘀证组(P<0.01)。结论大多数糖尿病患者都合并有血瘀。血瘀是糖尿病下肢动脉病变的重要致病因素。
Objective To investigate the relationship between diabetic lower extremity artery disease and blood stasis syndrome, and to provide evidence for prevention and treatment of diabetic lower extremity arterial disease in early stage. Methods 459 cases of diabetes patients were included in the basic information and clinical information collection and clinical diagnosis of lower extremity arterial disease. Syndromes and blood stasis syndrome group and no blood stasis syndrome group. 147 cases of them were detected arterial disease related indicators. To observe the relationship between diabetic lower extremity arterial disease and blood stasis syndrome. Results Nearly 75% of diabetic patients had blood stasis syndrome. The prevalence of diabetic lower extremity arterial disease (DLEAD) with blood stasis syndrome was significantly higher than that without blood stasis syndrome (P <0.01). The OR of blood stasis to estimate the risk of DLEAD was 4.737. The prevalence of peripheral arterial disease in both blood stasis syndrome group was significantly higher than that in no blood stasis syndrome group (P <0.01). Conclusion Most patients with diabetes mellitus have blood stasis. Blood stasis is an important pathogenic factor of diabetic lower extremity arterial disease.