非免疫性胎儿水肿的原因包括:染色体异常、Turner氏综合征、21三体、心脏结构异常或节律紊乱、巨细胞病毒、风疹病毒和人类细小病毒B19(HPV B19)等感染。但约44％的非免疫性水肿查不到原因。为评价HPV B19感染与非免疫性胎儿水肿的关系,通过PCR技术对Magee妇科医院1983～1992年间57例非免疫性水肿死亡胎儿的标本回顾分析,其中34例为特发性非免疫水肿,23例已知为 Causes of non-immune fetal edema include chromosomal abnormalities, Turner’s syndrome, trisomy 21, cardiac structural abnormalities or circadian rhythms, cytomegalovirus, rubella virus and human parvovirus B19 (HPV B19). However, about 44% of non-immune edema can not find the cause. To evaluate the relationship between HPV B19 infection and nonimmune fetal edema, we retrospectively analyzed the specimens from 57 non-immune edematous fetal deaths in Magee Women’s Hospital from 1983 to 1992, of which 34 were idiopathic non-immune edema and 23 Example known as