50年代初伪膜性结肠炎被认为是抗菌治疗的一个并发症。任何抗菌药物都有引起伪膜性结肠炎的可能,但常见于接受广谱抗菌素如四环素、氯霉素等治疗的患者。60年代此类报告较少。70年代以来,氨苄青霉素、林可霉素和氯林可霉素等广泛使用以后,患者发生腹泻和伪膜性结肠炎的报告增多 Pseudomembranous colitis is thought to be a complication of antibacterial therapy in the early 1950s. Any antibacterial drugs have the potential to cause pseudomembranous colitis, but common in patients receiving broad-spectrum antibiotics such as tetracycline, chloramphenicol and other treatment. There were fewer such reports in the 1960s. Since the 1970s, reports of diarrhea and pseudomembranous colitis have been reported in patients after extensive use of ampicillin, lincomycin and clindamycin