肝脏为细菌及其产物由肠道进入循环系统通道中之有效屏障。因其未能正常地进行除去内毒素之功能而可能引起肝脏损害或全身影响,在某些肝病中肠道内细菌内毒素起重要作用。如细菌产物确能加重肝脏损害之周围表现,则试行减少毒素之吸收或吸收后之毒性,可能对治疗有益。本进展报导将复习这些关系之证据,检验可能之机制并建议如何对这些表现能加以改进。内毒素及其他肝毒因素间之协同作用早在1941,磺胺类药已被发现能保护由四氯化碳引起之肝坏死及死亡,其稗益后经研究证实。Luckey等于1954研究了饮食性 The liver is an effective barrier for bacteria and their products from entering the circulatory system through the gut. Bacterial endotoxin plays an important role in the intestinal tract in some liver diseases due to its possible liver or systemic effects due to its failure to properly function to remove endotoxins. If bacterial products do aggravate the peripheral manifestations of liver damage, it may be beneficial to try to reduce the toxicity of toxins after absorption or absorption. This progress report will review the evidence of these relationships, examine possible mechanisms and advise on how these can be improved. Synergy between endotoxins and other hepatotoxic agents As early as 1941, sulfa drugs have been found to protect against hepatic necrosis and death caused by carbon tetrachloride. Luckey et al., 1954, studied diet