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关于肥胖可能是高血脂症、糖尿病、早发的动脉粥样硬化症以及夭亡等病的原因的设想,已经得到广泛地承认。临床的、流行病学的以及尸检资料都表明,与体瘦者对比,肥胖者的传染病发病率较高,与感染有关的死亡率也升高。以大量食物喂肥的狗缺乏抗鼠伤寒杆菌或病毒性疾病侵袭的宿主反应,因而其发病率和死亡率都较高。免疫的组织因素和非免疫的组织因素一样,例如,血管分布减少,体力活动减弱,呼吸运动受限制等构成肥胖对感染的敏感性的基础。关于对肥胖受试者的免疫机能的系统评价尚未见报道。我们观察了部份肥胖的青少年、儿童的免疫能力的降低情况,并发现免疫能力的降低与合并临床症状不明显的铁和锌缺乏有关。
The idea that obesity may be a cause of hyperlipidemia, diabetes, early-onset atherosclerosis and premature death has been widely recognized. Clinical, epidemiological and autopsy data indicate that obese individuals have a higher prevalence of infectious diseases and higher rates of infection-related mortality compared with those who are lean. Dogs fed large amounts of food lacking a host response to challenge with Salmonella typhimurium or viral disease and thus have a high morbidity and mortality. Immune tissue factors and non-immune tissue factor, for example, reduced vascular distribution, physical activity decreased, restricted respiratory movement and other forms of obesity based on the sensitivity of infection. Systematic reviews of immune function in obese subjects have not been reported. We observed a reduction in the immunocompetence of some obese adolescents and children and found that a decrease in immunity was associated with a combination of iron deficiency and zinc deficiency with poor clinical symptoms.