甘露醇是一种渗透性利尿剂,对预防急性肾功能衰竭有肯定疗效。现将作者两年来遇到的因输注大量甘露醇引起的急性肾功能衰竭4例报告如下,以引起人们重视。【例1】王某,男,58岁,因高血压8年,昏迷10小时入院。入院时右侧偏瘫,尿量及尿常规正常,BUN 4mmol/L,Cr67μmol/L。脑脊液为均匀血性,诊断为高血压脑出血。除支持疗法外,第一天输20％甘露醇200克后出现肉眼血尿,尿量为2500ml;第二、第三天每天输甘露醇100克,第四天200克,其间肉眼血尿消失,尿量从1800～2500ml降至第四天的500ml,第五天为250ml,BUN则上升至14.7mmol/L,Cr上升至248μmol/L,诊断为急性肾功能 Mannitol is an osmotic diuretic that has definite efficacy in the prevention of acute renal failure. Now the author encountered two years due to infusion of large amounts of mannitol caused by acute renal failure reported in 4 cases to draw attention. [Example 1] Wang, male, 58 years old, 8 years due to hypertension, coma 10 hours admitted. Right hemiplegia on admission, urine output and urine normal, BUN 4mmol / L, Cr67μmol / L. Cerebrospinal fluid is homogeneous bloody, diagnosis of hypertensive intracerebral hemorrhage. In addition to supportive therapy, the first day of 20% mannitol lost after 200 grams of gross hematuria, urine output of 2500ml; the second and third days of mannitol lost 100 grams daily, the fourth day of 200 grams, during which the disappearance of gross hematuria, urine The volume decreased from 1800-2500 ml to 500 ml on the fourth day, 250 ml on the fifth day, 14.7 mmol / L on BUN, and 248 μmol / L on Cr, which was diagnosed as acute renal function