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哺乳动物胎仔有父方和滋养层抗原,这些抗原常可导致母体产生细胞免疫和体液免疫。正常情况下机体的免疫调节有利于胎仔的存活。同种妊娠鼠子宫局部淋巴结和蜕膜中的非特异性抑制细胞在维持胎仔免受母体排斥中起关键作用。曾报导正常CBA/J雌鼠与DBA/2雄鼠交配,胎仔吸收率高,并缺乏这种抑制细胞。CBA/J雌鼠交配前预先用BALB/c雄鼠脾细胞免疫可消除胎仔吸收,但用DBA/2者则不能。母鼠对免疫用脾细胞的免疫应答是此种实验模型中妊娠成功的一个决定因素。但此动物模型另外一些特征指出,妊娠成功取决于多
Mammalian fetuses have both paternal and trophoblastic antigens, and these antigens can often lead to maternal cellular and humoral immunity. Under normal circumstances the body’s immune regulation is conducive to fetal survival. Non-specific suppression of lymphocytes in the lymph nodes and decidua of the same species in the uterus of pregnant rats plays a key role in maintaining fetus immunity from maternal rejection. It has been reported that normal CBA / J female mice mate with DBA / 2 males, have high rates of fetal absorption, and lack such inhibitory cells. CBA / J female mice preimpregnated with BALB / c male mouse spleen cell immunization can eliminate fetal absorption, but with DBA / 2 can not. The immune response of mother rats to immunization with splenocytes is a determining factor for the success of pregnancy in this experimental model. However, other features of this animal model indicate that the success of pregnancy depends on many