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在近50年中,胃癌的发病率呈急剧下降的趋势,但根据2008年国际癌症研究机构对全球肿瘤流行病统计数据得出胃癌是第三常见的肿瘤相关性死亡原因[1]。胃癌的发病有明显的地理差异性,日本、中国、东欧地区呈高发区域,而印度、北美、菲律宾和澳大利亚地区发病率较低[2]。原癌基因和抑癌基因的动态平衡决定着肿瘤的发生发展。基因治疗和分子靶向治疗在肿瘤领域已显示出了明显的优势。胃癌在组织学类
In the past 50 years, the incidence of gastric cancer has shown a sharp downward trend. However, according to the 2008 International Agency for Research on Cancer (IARC) statistics on global tumor epidemics, gastric cancer is the third most common cause of cancer-related death [1]. The incidence of gastric cancer has obvious geographical differences, Japan, China, Eastern Europe showed high incidence areas, while India, North America, the Philippines and Australia, the incidence was low [2]. The dynamic balance of proto-oncogene and tumor suppressor gene determines the development of tumor. Gene therapy and molecular targeted therapies have shown clear advantages in the field of oncology. Gastric cancer in histology