本文就苯二氮类药物的临床应用、效应与药动学关系、在肝肾病变时的代谢过程及药物相互作用进行了阐述。药代动力学:药代动力学性质的差异,对临床效应有重要影响,作为催眠药,其效应主要决定于服药后的吸收速度,催眠作用的出现是药物进入中枢神经系统的反应。该类药物的脂溶性较高,到达血流后,很快即进入中枢发挥效应。但各种药物的差异较大, In this paper, the clinical application of benzodiazepines, the relationship between effect and pharmacokinetics, metabolic processes in liver and kidney disease and drug interactions were described. Pharmacokinetics: Differences in pharmacokinetic properties have important implications for clinical effects. As a hypnotic drug, the effect is mainly determined by the rate of absorption after taking the drug. The appearance of hypnotic effects is a response of the drug to the central nervous system. The fat-soluble drugs of this type, reaching the bloodstream, enter the hub soon to play an effect. However, the difference between various drugs is larger,