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目的探讨妊娠期糖尿病(GDM)患者的胰岛素抵抗相关因素。方法以2012年10月-2014年9月141例妊娠期糖尿病患者为研究对象,即GDM组,并随机选择同一时期60名血糖正常的孕妇为对照(NC组),比较2组的一般情况、血液生化和免疫指标以及其他特异性指标的差异。结果 2组的年龄和孕周接近,差异无统计学意义、GDM组的BMI、FINS、FPG和HOMA-IR均高于NC组,差异有统计学意义;GDM组的脂联素、内肥素低于NC组,而瘦素、RBP-4和抵抗素高于NC组,差异有统计学意义;GDM组的CRP、TNF-α、IL-6、Hcy和Cys C均高于NC组,而FA低于NC组,差异有统计学意义;GDM组的TC、TG、LDL-C、Lp-a和Hb A1c高于NC组,而HDL-C低于NC组,差异有统计学意义。结论妊娠期糖尿病患者的胰岛素抵抗发生与多项指标相关,其作用机制有待进一步研究。
Objective To investigate the related factors of insulin resistance in gestational diabetes mellitus (GDM). Methods A total of 141 gestational diabetes patients from October 2012 to September 2014 were selected as GDM group and 60 pregnant women with normal blood glucose during the same period were selected as control group (NC group). The general situation, Blood biochemical and immune indicators and other specific indicators of differences. Results There was no significant difference in age and gestational age between the two groups. The BMI, FINS, FPG and HOMA-IR in GDM group were significantly higher than those in NC group (P <0.05) The levels of CRP, TNF-α, IL-6, Hcy and Cys C in GDM group were higher than those in NC group, while the levels of leptin, RBP-4 and resistin in NC group were higher than those in NC group FA was lower than NC group, the difference was statistically significant; TC, TG, LDL-C, Lp-a and Hb A1c in GDM group were higher than NC group, while HDL-C was lower than NC group, the difference was statistically significant. Conclusion The occurrence of insulin resistance in gestational diabetes mellitus is related to many indicators and its mechanism needs further study.