论文部分内容阅读
目的 在建立的哺乳动物整体生理药物动力学模型的基础上 ,导出了生理药物动力学模型参数 (分配系数R ,排泄速率常数KE;代谢速率常数KM)的计算公式。方法 并用此公式计算出了大鼠静脉注射环孢菌素A后的各器官或组织的分配系数。结果 本研究的计算方法可以计算出相应的数据。结论 本研究的参数估计方法可客观地计算出分配系数及药物动力学数据
OBJECTIVE: To derive the formula of physiological pharmacokinetic model parameters (partition coefficient R, excretion rate constant KE and metabolic rate constant KM) based on the establishment of the overall physiological pharmacokinetic model of mammals. Methods and using this formula to calculate the distribution coefficient of each organ or tissue after intravenous injection of cyclosporin A in rats. Results The calculation method of this study can calculate the corresponding data. Conclusion The parameter estimation method in this study can objectively calculate the partition coefficient and pharmacokinetic data