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目的：探讨维生素Ｂ族合用氟美松对硬膜外腔吗啡镇痛所致不良反应的预防效果。方法：以随机、双盲法对１８０例择期手术病人分为三组，每组６０例。分别于术后病人痛觉开始恢复时，自硬膜外腔注入。Ⅰ：吗啡３ｍｇ＋ｖｉｔＢ１１００ｍｇ＋ｖｉｔＢ６１００ｍｇ＋ｖｉｔＢ１２１０００μｇ＋氟美松１０ｍｇ。Ⅱ：吗啡３ｍｇ＋异丙嗪１２．５ｍｇ；Ⅲ（对照组）吗啡３ｍｇ。结果：Ⅰ组对防治吗啡镇痛所致的恶心、呕吐、皮肤瘙痒、腹胀，效果显著，与对照组相比较Ｐ＜０．０１；Ⅱ组对吗啡镇痛所致的皮肤瘙痒，效果显著，与对照组比较Ｐ＜０．０１。结果：ＶｉｔＢ族合用氟美松对吗啡镇痛所致的不良反应有良好的预防作用，有一定的临床应用及推广价值。
Objective: To investigate the preventive effect of Vitamin B combination with dexamethasone on adverse reactions induced by epidural morphine analgesia. Methods: A total of 180 patients undergoing elective surgery were randomly divided into three groups (60 in each group). Respectively in patients with postoperative pain began to recover from the epidural space injection. Ⅰ: Morphine 3mg + vitB1100mg + vitB6100mg + vitB121000μg + dexamethasone 10mg. Ⅱ: morphine 3mg + promethazine 12.5mg; Ⅲ (control group) morphine 3mg. Results: In group Ⅰ, nausea, vomiting, skin pruritus and abdominal distention caused by morphine analgesia were significantly inhibited, compared with the control group (P <0.01). In group Ⅱ, pruritus caused by morphine analgesia was significant, Compared with the control group, P <0.01. RESULTS: VitB combined with dexamethasone had a good preventive effect on adverse reactions caused by morphine analgesia, and had certain clinical application and promotion value.