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近年来,在急性冠脉综合征(ACS)患者的粥样斑块中和外周血中发现一种不寻常的T细胞,CD4+CD28-T淋巴细胞,IL-12使它CCR-5的表达增加,CCR-5与粥样硬化病变中MIP-1α/CCL3和RANTES/CCL5结合促进CD4+CD28-T淋巴细胞的聚集,这种细胞既表现效应性记忆细胞的特性,又具有中心记忆性T细胞的特性,表现在产生大量干扰素-γ,细胞溶解功能和在体内能杀死内皮细胞和血管平滑肌细胞(VSMCs)功能、克隆扩增性和长寿命性,促进动脉粥样硬化斑块不稳定性,与ACS的发病密切相关。其研究结果对ACS的预防和治疗提供新的途径。
In recent years, an unusual T cell, CD4 + CD28-T lymphocyte, has been found in atherosclerotic plaque and peripheral blood in patients with acute coronary syndrome (ACS), which causes its expression of CCR-5 CCR-5 binds to MIP-1α / CCL3 and RANTES / CCL5 in atherosclerotic lesions to promote the aggregation of CD4 + CD28-T lymphocytes, which express both effector memory cells and central memory T Cell characteristics, manifested in the production of a large number of interferon-gamma, cytolytic function and in vivo can kill endothelial cells and vascular smooth muscle cells (VSMCs) function, clonal expansion and long-lived, and promote atherosclerotic plaque Stability, and the incidence of ACS is closely related. The results provide a new way for the prevention and treatment of ACS.