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目的:评价我国综合医院医院感染所致直接经济损失。方法抽取综合医院68所,回顾性调查2015年1月1日—12月31日68所医院医院感染与非医院感染病例,采用1!1匹配的方法进行配对,比较医院感染与非医院感染患者直接医疗费用。结果共纳入2123对医院感染与非感染病例,医院感染组平均住院总费用为25845.30元,非医院感染组为12006.14元,医院感染直接导致住院费用增加13839.16元。省部级医院医院感染所致直接经济损失较多(21409.83元)。不同地区医院感染所致直接经济损失为9725.42~18909.59元,其中华北地区直接经济损失最多。血流感染、下呼吸道感染所致直接经济损失较大,分别是23190.09、18194.50元。结论医院感染导致较大直接经济损失,应进一步加强医院感染,尤其是血流感染、下呼吸道感染的防控工作。“,”Objective To explore the direct economic loss caused by healthcare-associated infection(HAI)in general hospitals in China.Methods 68 hospitals were selected,a retrospective 1:1 matched survey was conducted to compare the direct medical cost in patients with and without HAI between January 1,2015 and December 31,2015. Results A total of 2 123 pairs of patients with and without HAI were included in the survey.The average cost of hospitalization in HAI and non-HAI groups were ¥25 845.30 and ¥12 006.14 respectively,¥13 839.16 on average was increased due to HAI.The average economic loss in provincial and ministerial levels of hospitals were¥21 409.83.The average economic loss in different regional hospitals were ¥9 725.42-¥18 909.59,and north China ranked the first.Economic loss caused by bloodstream infection and lower respiratory tract infection were more than other sites,which were ¥23 190.09 and ¥18 194.50 respectively.Conclusion HAI resulted in considerable direct economic loss.Prevention and control of HAI,especially bloodstream infection and lower respiratory tract infection should be paid more attention.