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目的探讨亚临床甲状腺功能减退与自然流产的相关性,以避免反复流产的发生,提高正常妊娠率。方法 150例早孕妇女作为研究对象,有2次及2次以上自然流产史为A组,1次自然流产史为B组,无不良孕史为C组,各50例。用电化学发光法检测并比较促甲状腺素(TSH)和游离甲状腺素(FT4)。结果亚临床甲状腺功能减退患病率A组28.00%,B组22.00%,C组6.00%。A组与B组比较,差异无统计学意义(P>0.05);A组与C组、B组与C组比较,差异均有统计学意义(P<0.05)。结论亚临床甲状腺功能减退与自然流产有明显相关性,与自然流产次数无明显相关性,对于有不良孕史早孕妇女应常规筛查并尽早积极治疗。
Objective To investigate the correlation between subclinical hypothyroidism and spontaneous abortion in order to avoid repeated abortion and improve the normal pregnancy rate. Methods 150 cases of early pregnant women as the research object, there are 2 or more times the history of spontaneous abortion for the A group, a history of spontaneous abortion in the B group, no history of adverse pregnancy in the C group, 50 cases. Electrochemiluminescence was used to detect and compare thyrotropin (TSH) and free thyroxine (FT4). Results The prevalence of subclinical hypothyroidism was 28.00% in group A, 22.00% in group B and 6.00% in group C. There was no significant difference between group A and group B (P> 0.05). There was significant difference between group A and group C, group B and group C (P <0.05). Conclusions Subclinical hypothyroidism has obvious correlation with spontaneous abortion and has no obvious correlation with the number of spontaneous abortion. For pregnant women with poor pregnancy history, pregnant women should be routinely screened and actively treated as soon as possible.