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目的观察氟伐他汀对早期糖尿病肾病(DN)大鼠模型尿液中蛋白排泄的影响,探讨氟伐他汀对早期DN肾脏的保护作用。方法 55只大鼠分为正常对照组(N组,10只)、糖尿病肾病组(DN组,15只)、DN+氟伐他汀组(DNF组,15只)、DN+缬沙坦组(ARB组,15只)。DN组DNF组与ARB组均给予链尿佐菌素(STZ)55 mg/kg单次腹腔注射。两周后DNF组给予2 mg/kg氟伐他汀灌胃;ARB组灌以15 mg/kg的缬沙坦;剩余两组则予以同剂量蒸馏水。4周后测各组大鼠尿白蛋白(UAlb)、单核细胞趋化蛋白-1(MCP-1)、尿肌酐(Ucr),计算UAlb/Ucr和尿MCP-1/Ucr。结果 D与N组比较,DN组的UAlb/Ucr及尿MCP-1/Ucr显著升高(P<0.01),而DNF组、ARB组大鼠尿UAlb/Ucr及尿MCP-1/Ucr均显著低于DN组(P<0.01)。结论氟伐他汀可有效减少DN大鼠尿中MCP-1及UAlb,对肾脏有一定保护作用。
Objective To observe the effect of fluvastatin on protein excretion in the urine of early diabetic nephropathy (DN) rats and to explore the protective effect of fluvastatin on early DN kidney. Methods Fifty-five rats were divided into normal control group (n = 10), diabetic nephropathy group (n = 15), DN + fluvastatin group (n = 15), DN + valsartan group , 15). DN group DNF group and ARB group were given streptozotocin (STZ) 55 mg / kg single intraperitoneal injection. Two weeks later, DNF group was given fluvastatin 2 mg / kg; ARB group was given valsartan 15 mg / kg; the remaining two groups were given the same dose of distilled water. After 4 weeks, the urinary albumin (UAlb), monocyte chemoattractant protein-1 (MCP-1), urinary creatinine (Ucr), UAlb / Ucr and urinary MCP-1 / Ucr were calculated. Results Compared with N group, UAb / Ucr and urinary MCP-1 / Ucr in DN group were significantly increased (P <0.01), but urinary UAb / Ucr and urinary MCP-1 / Ucr in DNF group and ARB group were significantly Lower than DN group (P <0.01). Conclusion Fluvastatin can reduce MCP-1 and UAlb in the urine of DN rats effectively and has a protective effect on the kidney.