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乳腺癌是我国女性常见的恶性肿瘤,且发病率呈逐年增高趋势。尽管乳腺癌在早期诊断和综合治疗方面都有了很大的进步,但肿瘤远处转移仍严重影响患者的预后[1]。本文对目前乳腺癌微小转移灶的研究状况做一综述,并结合近年来的有关国外文献,探讨微小转移灶的临床意义。自从Ash-worth首次证实在血液中发现癌细胞以来,人们将它称为肿瘤细胞微小转移病灶(micrometastases)、微小残存病灶(min-imal residual disease,MRD)、循环肿瘤细胞(circulating tumorcells,CTCs)、潜伏肿瘤细胞(occult tumor cells,OTCs)等。
Breast cancer is a common malignant tumor in Chinese women, and the incidence showed a trend of increasing year by year. Although breast cancer has made great advances in the early diagnosis and comprehensive treatment, distant metastasis of tumor still seriously affects the prognosis of patients [1]. This review summarizes the current status of the study on micrometastases in breast cancer, and discusses the clinical significance of micrometastases in combination with the relevant foreign literature in recent years. Since Ash-worth first confirmed the discovery of cancer cells in the bloodstream, it has been described as micrometastases, min-imal residual disease (MRD), circulating tumor cells (CTCs) , Occult tumor cells (OTCs) and the like.