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目的:探讨卵巢癌患者病灶间质中及上皮内CD3+TILs、CD4+TILs、CD8+TILs、Treg的分布特点。方法:采用免疫组织化学方法检测40例卵巢癌患者病灶间质中及上皮内CD3+TILs、CD4+TILs、CD8+TILs、Treg的表达情况及10例正常卵巢组织中CD3+T细胞、CD4+T细胞、CD8+T细胞、Treg的表达情况。结果:卵巢癌组织中CD3+T细胞、CD4+T细胞、CD8+T细胞数量与正常卵巢组织中相比显著增加,且卵巢癌组织上皮内Treg数量增加。结论:卵巢癌局部微环境中机体对肿瘤抗原可以产生免疫反应,但Treg的存在而抑制了肿瘤的特异性免疫。
Objective: To investigate the distribution of CD3 + TILs, CD4 + TILs, CD8 + TILs and Tregs in interstitial and epithelial tissues of patients with ovarian cancer. Methods: The expressions of CD3 + TILs, CD4 + TILs, CD8 + TILs and Tregs in the stromal and epithelial tissues of 40 ovarian cancer patients and the expression of CD3 + T cells and CD4 + T cells in 10 normal ovarian tissues were detected by immunohistochemistry. T cells, CD8 + T cells, Treg expression. Results: The number of CD3 + T cells, CD4 + T cells and CD8 + T cells in ovarian cancer tissues increased significantly compared with that in normal ovarian tissues, and the number of Tregs in ovarian cancer tissues increased. Conclusion: The body microenvironment in ovarian cancer can produce immune response to tumor antigens, but the existence of Treg inhibits tumor specific immunity.