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目的:观察五苓散分别加活血祛瘀药三七、丹参和清火化痰开窍药石菖蒲、夏枯草后,对血管源性脑水肿的疗效差异,并探讨引起差异的机理。方法:用自体无肝素新鲜血注入法制作脑出血脑水肿动物模型,观察并检测12h和24h两个时间点的脑系数、脑含水量、伊文思蓝含量。结果:两中药组在降低脑系数、脑含水量、伊文思蓝含量上差异均有显著性(P<0.01),其中健神利水Ⅰ号作用优于醒脑消肿胶囊(P<0.05)。结论:本实验表明,在12h内已出现血管源性水肿,并随时间推移脑水肿有进一步加重的趋势;加用三七、丹参的五苓散(即健神利水Ⅰ号)与加石菖蒲、夏枯草的五苓散(即醒脑消肿胶囊)比较,健神利水Ⅰ号对血脑屏障的保护作用要强于醒脑消肿胶囊。
OBJECTIVE: To observe the difference in the therapeutic effect of Wuyi Powder and Huoxue Pills Sanqi, Salvia Miltiorrhiza and Qinghuo Huayu Herbal Medicine Shichangpu and Prunella vulgaris on vasogenic brain edema, and to explore the mechanism of the differences. METHODS: An animal model of intracerebral hemorrhage brain edema was made with autologous heparin-free fresh blood injection method. The brain coefficient, brain water content and Evans blue content were observed and measured at 12h and 24h. Results: There was significant difference in reducing brain coefficient, brain water content and Evans blue content between the two Chinese medicine groups (P<0.01). Among them, Jianshen Lishui I was better than Xingnao Xiaozhong Capsule (P<0.05). Conclusion: This experiment shows that vasogenic edema has occurred within 12 hours, and brain edema has been further aggravated over time; plus Wuqisan (ie, Jianshen Lishui I) plus Jiashipu of Sanqi and Salvia miltiorrhiza. Compared with Prunella vulgaris (ie, Xingnaoxiaoshang capsule), Jianshen Lishui I had stronger protective effect on the blood-brain barrier than Xingnao swelling capsule.