自噬(autophagy)是细胞依赖溶酶体对胞内蛋白质和受损细胞器进行降解的一条重要途径。细胞自噬受各种因子的精密调节,是细胞清除损伤物质和维持细胞稳态的重要调节方式,与心血管疾病、肿瘤和神经退行性疾病发生密切相关~([1])。近几年有文献报道病毒性心肌炎中存在细胞自噬现象~([2~4]),结合作者前期试验在小鼠病毒性心肌炎模型中亦观察到细胞自噬现象,因此本文就自噬与病毒性心肌炎的关系进行综述。 Autophagy is an important pathway for cell-dependent lysosomes to degrade intracellular proteins and damaged organelles. Cell autophagy is closely regulated by various factors and is an important regulative way for cells to remove damaged substances and maintain cell homeostasis. It is closely related to cardiovascular diseases, tumors and neurodegenerative diseases ([1]). In recent years, there are reports of autophagy in viral myocarditis ~ ([2 ~ 4]), combined with the previous study in mice with viral myocarditis model also observed autophagy, so in this paper, autophagy and The relationship between viral myocarditis is reviewed.