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伪膜性肠炎(Pseudomembranouscolitis,PMC)是病理改变以伪膜为特征的结肠炎症。多数与抗生素的使用有关,又称抗生素相关肠炎(AAC),PMC是AAC中最严重的一种。近十年来证明,难辨梭菌是其最重要的病原菌。一、PMC的研究历史 1.抗生素应用之前:Finney(1893)描述一例胃肠手术后患“伪白喉性肠炎”的病人。接着对各种危险因素进行研究后指出:肠缺血是致病因素,在肠术后、肠梗阻、结肠癌、尿毒症、重金属中毒及缺血性心脏病时常可发生。多在尸解时确立诊断。
Pseudomembranous colitis (PMC) is a pathological change in colonic pseudomembranous inflammation. Mostly associated with the use of antibiotics, also known as antibiotic-associated enteritis (AAC), PMC is the most serious AAC. Over the past decade to prove that Clostridium difficile is the most important pathogen. First, the history of PMC research 1. Antibiotics before: Finney (1893) describes a case of gastrointestinal surgery suffering from “pseudo-diphtheria enteritis” in patients. Followed by a variety of risk factors after the study pointed out: intestinal ischemia is a causative factor in intestinal surgery, intestinal obstruction, colon cancer, uremia, heavy metal poisoning and ischemic heart disease can often occur. Set up a diagnosis at the time of autopsy.