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目的:观察复方中药二黄丹安方抗巨细胞病毒作用。方法:用细胞病变法和噻唑蓝法体外研究二黄丹安方抗巨细胞病毒的最大无毒浓度、最小有效浓度和治疗指数,并与更昔洛韦进行比较。结果:二黄丹安方和更昔洛韦的最大无毒浓度分别为3 000μg/ml和100μg/ml,最小有效浓度为30μg/ml和10μg/ml,治疗指数分别为100和10。结论:二黄丹安方具有体外抗巨细胞病毒作用;其抗病毒作用略低于更昔洛韦,细胞毒性远低于更昔洛韦,治疗指数高于更昔洛韦,有望成为预防巨细胞病毒宫内感染的药物。
Objective: To observe the anti-cytomegalovirus effect of the two traditional Chinese medicines. Methods: The maximum non-toxic concentration, the minimum effective concentration and the therapeutic index of Diazepam anti-cytomegalovirus were studied by cytopathic assay and thiazolyl blue assay in vitro and compared with ganciclovir. RESULTS: The maximum non-toxic concentrations of ditriandine and ganciclovir were 3 000 μg / ml and 100 μg / ml, respectively. The minimum effective concentrations were 30 μg / ml and 10 μg / ml. The therapeutic indices were 100 and 10, respectively. Conclusion: Diazandanfang has the anti-cytomegalovirus effect in vitro; its antiviral effect is slightly lower than that of ganciclovir, the cytotoxicity is much lower than that of ganciclovir, the treatment index is higher than that of ganciclovir, and it is expected to be a cytomegalovirus for preventing cytomegalovirus Intrauterine infection of the drug.