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目的：了解医院住院患者金黄色葡萄球菌医院感染分布及其耐药性状况，为控制医院感染和合理选用抗菌药物提供依据。方法采用回顾性调查方法，对某医院住院患者送检标本中分离出的金黄色葡萄球菌及其耐药性检测结果进行统计分析。结果该医院在2011-2013年期间从住院患者送检标本中共分离出金黄色葡萄球菌359株，其中耐甲氧西林金黄色葡萄球菌（ MRSA）占18.67%。MRSA感染患者中，呼吸道感染占46.27%，明显高于其他部位感染。临床分离的金黄色葡萄球菌对临床常用抗菌药物普遍耐药，MRSA菌株仅对利奈唑胺、万古霉素和替考拉宁敏感。结论该医院临床分离的金黄色葡萄球菌主要来自呼吸道标本，呈现普遍耐药，MRSA菌株耐药率明显高于对甲氧西林敏感金黄色葡萄球菌（ MSSA）菌株。“,”Objective To know the clinical distribution and drug resistance of Staphylococcus aureus in patients with noso-comial infection,and provide basis for clinical rational selection of drugs and the nosocomial infection control. Methods Retrospective survey was used to analyze drug resistant rate of Staphylococcus aureus isolated from the specimens of the in-patient. Results A total of 359 strains of Staphylococcus aureus were isolated from the specimens which obtained from the hospitalized patients from 2011 to 2013,including 18. 67% strains of methicillin-resistant Staphylococcus aureus. MRSA infection in patients with respiratory tract infection accounted for 46. 27%,significantly higher than other infected areas. The Staphylococcus aureus were resistant to the commonly used antibiotics,MRSA strains were only sensitive to linezolid, vancomycin and teicoplanin. Conclusion Staphylococcus aureus is mainly from respiratory tract specimens,and shows widespread drug resistance in the hospital. The drug resistance of MRSA strains were significantly higher than the MSSA strains.