Enoxacin(CI-919,AT-2266)是一新的羟基吡啶羧酸(pyridonecarboxylicacid)衍生物,有广谱抗菌活性.体外试验表明其对革蓝氏阳性菌、革蓝氏阴性菌(包括绿脓杆菌)有较托普霉素、艮他霉素、氨苄青霉素和某些第三代头孢菌素更为广的抗菌谱;大鼠和小鼠的体内研究提示其口服吸收良好,在心、肌肉、肺、肝和肾组织内均有高浓度;给予试验剂量时也无血液、肝或肾毒性发生.Enoxacin用于由各种细菌包括肠杆菌、葡萄球菌和假单胞菌等所致的实验 Enoxacin (CI-919, AT-2266) is a novel pyridonecarboxylic acid derivative with broad spectrum antibacterial activity. In vitro tests show that it is effective against Gram-positive bacteria, Bacilli) than tobramycin, gentamicin, ampicillin and some third-generation cephalosporins broader antimicrobial spectrum; in vivo studies in rats and mice suggest that its oral absorption of good, in the heart, muscle, High concentrations are present in lung, liver and kidney tissues; no blood, liver or nephrotoxicity occurs at the dose administered. Enoxacin is used in experiments resulting from various bacteria, including Enterobacteriaceae, Staphylococcus and Pseudomonas