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肿瘤的侵袭转移是导致肿瘤患者死亡的主要原因,寻找引发肿瘤细胞侵袭与转移的因素并进行有效阻断是治疗肿瘤的重要方法之一。肿瘤细胞要实现侵袭和转移首先要穿越由细胞外基质(extracellularmatrix,ECM)及基底膜(basement mem-brane,BM)组成的屏障。该屏障主要由Ⅳ胶原(collage
Tumor invasion and metastasis is the leading cause of death in cancer patients. Looking for factors that lead to invasion and metastasis of tumor cells and effective blocking is one of the important ways to treat cancer. To achieve invasion and metastasis, tumor cells must first pass through a barrier composed of extracellular matrix (ECM) and basement mem-brane (BM). The barrier mainly by Ⅳ collagen (collage