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目的评估血管内皮生长因子C(VEGF-C)、淋巴管密度(LMVD)与结肠癌临床病理指标及预后的关系。方法用免疫组织化学法检测44例原发结肠癌VEGF-C和VEGF受体-3(VEGFR-3)表达,计数LMVD,分析上述指标与临床病理指标和预后的关系。结果本组结肠癌VEGF-C阳性表达率为43.2%(19/44),LMVD为10.14±4.19。VEGF-C表达与肿瘤分化程度(P=0.003)、淋巴结转移(P=0.002)和Dukes分期(P=0.001)相关。LMVD与淋巴结转移(P=0.001)和Dukes分期(P=0.001)相关。VEGF-C表达阳性组LMVD为11.34±4.83,高于VEGF-C表达阴性组的9.24±3.48,但VEGF-C与LMVD无相关性(P=0.105)。VEGF-C阳性组患者生存率明显低于阴性组(P=0.0225),LMVD阳性组患者生存率明显低于阴性组(P=0.0036)。远处转移(P=0.0004)、淋巴结转移(P=0.021)和LMVD(P=0.0469)可以作为结肠癌独立的预后因素。结论VEGF-C和LMVD对于判断结肠癌侵袭性和预后有重要参考价值。LMVD可以作为判断结肠癌预后的独立指标。
Objective To evaluate the relationship between vascular endothelial growth factor C (VEGF-C), lymphatic vessel density (LMVD) and clinicopathological parameters and prognosis of colon cancer. Methods The expressions of VEGF-C and VEGFR-3 in 44 cases of primary colon cancer were detected by immunohistochemistry. The expression of VEGFR-3 was detected by LMVD. The relationship between the above indexes and clinicopathological parameters and prognosis was analyzed. Results The positive rate of VEGF-C in colon cancer was 43.2% (19/44) and LMVD was 10.14 ± 4.19. VEGF-C expression correlated with tumor differentiation (P = 0.003), lymph node metastasis (P = 0.002) and Dukes stage (P = 0.001). LMVD was associated with lymph node metastasis (P = 0.001) and Dukes stage (P = 0.001). The positive expression of VEGF-C in LMVD was 11.34 ± 4.83, which was higher than that of negative group (9.24 ± 3.48), but there was no correlation between VEGF-C and LMVD (P = 0.105). The survival rate in patients with VEGF-C positive was significantly lower than that in patients with negative (P = 0.0225). The survival rate in patients with positive LMVD was significantly lower than that in patients with negative (P = 0.0036). Distant metastasis (P = 0.0004), lymph node metastasis (P = 0.021) and LMVD (P = 0.0469) were independent prognostic factors for colon cancer. Conclusion VEGF-C and LMVD have important reference value for judging the invasiveness and prognosis of colon cancer. LMVD can be used as an independent indicator of the prognosis of colon cancer.