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单核苷酸多态性(singlenucleotidepolymorphisms,SNP)指基因组内特定核酸位置上存在两种不同的碱基,其中最少一种在群体中的频率不小于1%.研究发现SNP与疾病的遗传易感性密切相关.细胞因子(cytokine,CK)是由活化的免疫细胞和某些基质细胞分泌的具有高活性、多功能的小分子多肽类物质,通过与特异性受体结合发挥前炎症因子的生物学效应.目前的分类有:白细胞介素(IL)、肿瘤坏死因子(TNF)、干扰素(IFN)等.幽门螺杆菌Hpylori感染能导致细胞因子表达增加,胃黏膜炎症反应加重,引起炎症损伤.近年来,细胞因子单核苷酸多态性与Hpylori感染在胃疾病的发生过程中的关系的研究备受重视,现综述如下.
Single nucleotide polymorphisms (SNPs) refer to the presence of two different bases at specific nucleic acid positions in the genome, with at least one frequency of at least 1% in the population. The study found that genetic susceptibility to SNPs and disease Closely related.Cytokine (cytokine, CK) is activated by immune cells and some stromal cells secrete high activity, multi-functional small molecule peptides, by binding to specific receptors to play the role of pro-inflammatory cytokines The current classification is: interleukin (IL), tumor necrosis factor (TNF), interferon (IFN), etc. Helicobacter pylori Hpylori infection can lead to increased expression of cytokines, increased inflammation of the gastric mucosa, causing inflammatory damage. In recent years, cytokine single nucleotide polymorphisms and Hpylori infection in the pathogenesis of gastric disease has received great attention, are summarized below.