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p27~(kipl)是近年发现的抑癌基因,p27~(kiPl)基因及其产物对于细胞的生长及其肿瘤发生发展和转移有着及其重要的作用。其位于细胞核内,在人体染色体12p12.0～12p13.1交接处。 1 p27~(kiPl)的生物学功能及作用机制 p27~(kipl)主要通过抑制CDK来抑制细胞周期。p27~(kipl)对CDK的抑制主要有三个方面:①通过其C末端抑制Cdk2-Thr160的磷酸比,从而抑制细胞周期蛋白-CD2的前活性状态复合物的激活过程,使CDK处于非活性状态对细胞周期实现负调空。②通过直接与细胞周期蛋白-CDK结合抑制已激活的复合物的激酶活性。③通过阻断Rb蛋白的磷酸化形式控制细胞周期的进程;④p27~(kipl)基因可作为启动子诱导细胞凋亡。⑤p27~(kipl)具有抗炎症损失作用;⑥p27~(kipl)对细胞增殖的启动和放大起决定作用;⑦P27~(kipl)具有诱导未成熟的细胞分化的作用。以上表明p27~(kiPl)的积聚既部分参与
P27~(kipl) is a tumor suppressor gene discovered in recent years. The p27~(kiPl) gene and its products play an important role in the growth of cells and the development and metastasis of their tumors. It is located in the nucleus where human chromosomes 12p12.0 to 12p13.1 meet. 1 p27 ~ (kiPl) biological function and mechanism of action p27 ~ (kipl) mainly by inhibiting CDK to inhibit cell cycle. The inhibition of CDK by p27~kipl has three main aspects: 1 The phosphoryl ratio of Cdk2-Thr160 is inhibited by its C-terminus, thereby inhibiting the activation process of the pre-active complex of cyclin-CD2 and rendering the CDK inactive. Negative adjustments to the cell cycle. 2 Inhibition of the kinase activity of the activated complex by direct binding to cyclin-CDK. 3 By controlling the phosphorylation of the Rb protein, it controls the progression of the cell cycle; the 4p27kip gene can act as a promoter to induce apoptosis. 5p27~(kipl) has an anti-inflammatory effect; 6p27~kipl plays a decisive role in the initiation and amplification of cell proliferation; 7P27~kipl has the effect of inducing immature cell differentiation. The above shows that the accumulation of p27~(kiPl) is partly involved