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目的:为确定125 I-间碘代苄基胍(125 I-MIBG)是否有类胺作用,于离体的兔心中探测125 I-MIBG的拟交感神经效应,并与14C-酪胺比较。方法:静脉给予家兔肝素(500U)和过量的戊巴比妥钠(80mg/kg),处死后迅速取出心脏。在剂量为0.03～10μmol/L的125 I-MIBG或14C-酪胺弹丸式注入主
PURPOSE: To determine whether 125 I-MIBG acts as a class amine, the sympathetic nerve effect of 125 I-MIBG was detected in isolated rabbit hearts and compared with 14 C-tyramine. Methods: Rabbit heparin (500U) and excessive sodium pentobarbital (80mg / kg) were given intravenously and the heart was removed rapidly after sacrifice. In the dose of 0.03 ~ 10μmol / L of 125 I-MIBG or 14C-tyramine bolus injected into the main