作者用大剂量鞘内注射氯苯氨丁酸治疗了11名3～18岁的儿童大脑强直状态的患者,疗效显著。患者一次给药50～2000μg,然后按需要增加剂量,最高者达700μg。大多数患者所需有效量为100或100μg 以上。剂量的大小大多取决于疾病的严重程度而不是年龄。在10名显效的患者中,植入泵系统使每日的氯苯氨丁酸的鞘内释放量达25～700μg。结果,所有患者的大脑强直状态均见减弱,虽有几名患者需增加剂量,其中1人在4年的鞘内治疗中每日剂量需增加100～700μg。有一名顽固性癫痫发作患者,鞘内注 The authors used high-dose intrathecal chlorpromazine to treat 11 patients aged 3 to 18 years with brain tonic status in patients with significant effect. Patients once administered 50 ~ 2000μg, and then increase the dose as needed, the highest up to 700μg. The effective amount required for most patients is 100 or more. The size of the dose depends largely on the severity of the disease and not on age. In 10 markedly effective patients, a pump system was implanted to deliver daily doses of 25 to 700 μg of clofibrate. As a result, all patients experienced weakened brain tonic status. Although several patients required additional doses, one required an increase of 100 to 700 μg daily for 4 years of intrathecal treatment. One patient with intractable seizures, intrathecal injection