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观察了４０例Ⅱ型糖尿病（ＮＩＤＤＭ）伴发冠心病（ＣＨＤ）患者及３２例ＮＩＤＤＭ无心脑肾并发症患者（对照组）血脂水平及丙二醛（ＭＤＡ）和超氧化物歧化酶（ＳＯＤ）的血清含量，结果显示，除胆固醇外，其余各指标两组间均有显著差异。ＣＨＤ组ＭＤＡ明显高于对照组，而ＳＯＤ则明显低于对照组。多元线性相关分析表明，低密度脂蛋白胆固醇与ＭＤＡ呈显著正相关（ｒ＝０．５７１２；Ｐ＜０．００１）。高密度脂蛋白胆固醇与ＳＯＤ呈显著正相关（（ｒ＝０．５１１２；Ｐ＜０．００１）。提示ＮＩＤＤＭ患者伴发冠心病高脂血症与脂质过氧化间有一定的关系。
The levels of plasma lipids, malondialdehyde (MDA) and superoxide dismutase (SOD) in 40 patients with type 2 diabetes mellitus (NIDDM) accompanied with coronary heart disease (CHD) and 32 patients with NIDDM without heart and brain complications ) Serum levels, the results showed that, in addition to cholesterol, the rest of the indicators between the two groups were significantly different. MDA in CHD group was significantly higher than that in control group, while SOD was significantly lower than that in control group. Multivariate linear correlation analysis showed that there was a significant positive correlation between LDL cholesterol and MDA (r = 0.5712; P <0.001). There was a significant positive correlation between high density lipoprotein cholesterol and SOD (r = 0.5112; P <0.001), suggesting that there is a relationship between hyperlipidemia and lipid peroxidation in patients with NIDDM.