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本文对非肥胖的及肥胖的NIDDM病人及其相应正常对照共四个实验组进行红细胞胰岛素受体实验,结果是Ⅰ组(非肥胖NIDDM,n=27)的高亲和力胰岛素受体结合位点数目Q_1及其亲和常数K_1(代表亲和力)为四组中最多及大;反之,Ⅱ组(肥胖的NIDDM,n=30)的Q_1及K_1为四组中最少及小。虽然在统计学上的显著性不够(由于例数偏少,s.偏大),但是可以看出趋向性,提示非肥胖NIDDM的胰岛素抵抗性与受体结合可能无关,病因可能在受体后(细胞内),而肥胖的NIDDM则相反,其病因不能排除与受体结合上的缺陷有关。
In this study, non-obese and obese patients with NIDDM and its corresponding normal control, a total of four experimental groups erythrocyte insulin receptor test results in group Ⅰ (non-obese NIDDM, n = 27) high affinity insulin receptor binding sites Q_1 and its affinity constant K_1 (representing affinity) were the largest and the largest among the four groups. In contrast, Q_1 and K_1 in group Ⅱ (obese NIDDM, n = 30) were the least and the smallest of the four groups. Although not statistically significant (due to a small number of cases, s. Is too large), but we can see the trend, suggesting that non-obese NIDDM insulin resistance and receptor binding may be unrelated to the etiology may be in the receptor (Intracellular), while obese NIDDM, on the other hand, can not be ruled out by its etiology associated with receptor-associated defects.